MEANING OF ZOLLINGER-ELLISON SYNDROME

MEANING OF ZOLLINGER-ELLISON SYNDROME

Zollinger-Ellison syndrome a rare disorder in which there is excessive secretion of gastric juice due to high levels of circulating *gastrin, which is produced by a pancreatic tumour (see GASTRINOMA) or an enlarged pancreas. The high levels of stomach acid cause diarrhoea and peptic ulcers, which may be multiple, in unusual sites (e.g. jejunum), or which may quickly recur  after *vagotomy or partial *gastrectomy. Treatment with proton-pump   inhibitors, by removal of the tumour (if benign), or by total gastrectomy is usually effective. [R. M. Zollinger (1903–92) and E. H. Ellison (1918–70), US physicians]

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