This medicine contains as active ingredient ziprasidone, a psychoactive medicine that influences the activity of the brain; by affecting serotonin and dopamine, neurotransmitters in the brain, normalizing their chemical balance and relieving symptoms of   schizophrenia.

It is effective in reducing the violent aggressive manifestations of mental illnesses such as schizophrenia, mania, Alzheimer’s dementia, and other disorders in which hallucinations are  experienced.

Prescribed for

The drug is prescribed for:

•   Schizophrenia

•   Psychotic behavior

•   Acute agitation in schizophrenia

•   Bipolar mania (both major and mixed episodes)

Before using this medicine

Before you use this medicine check with your  doctor:

•   if you ever had any unusual or allergic reaction to haloperidol.

•    if you are pregnant or intend to become pregnant while using this medicine. Decide with your doctor if the drug benefits justify the risk to the unborn child.

•    if you are breast-feeding an infant. The drug passes into the breast milk. Avoid the drug or discontinue nursing until you finish the medicine.

•   if you have suffering from a depression.

•   if you have Parkinson’s disease.

Cautions and Warnings

•    This medicine should not be used in people with dementia-related psychosis.

•    This medicine can increase blood sugar, worsen diabetes, and may push pre-diabetes into true clinical diabetes. People with diabetes and those at risk for diabetes taking this medicine must regularly monitor their blood sugar levels.

•    The medicine can affect heart function, leading to potentially fatal heart rhythms; it may affect the heart more acutely than other antipsychotic medicines. The chances of developing this abnormal heart rhythm increases if your blood potassium or magnesium levels are too low.

•    Neuroleptic malignant syndrome, a potentially fatal group of symptoms associated with this medicine and other psychoactive drugs, can occur. Important symptoms of this syndrome are:

•   High fever

•   Muscle rigidity

•   Mental changes

•   Irregular pulse

•   Rapid heartbeat

•   Sweating

•    Antipsychotic drugs, including this medicine, may cause involuntary movements of the face and tongue called tardive dyskinesia, which may become permanent.

•   Contact your doctor if you develop any of these side effects.


This medication is used to relieve or prevent the symptoms of your medical problem affecting your brain  function.

Usual dose:The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your  doctor may prescribe a different regime. The starting dose for  adults amounts to 20 milligrams twice a day. Some patients may need 60-80 milligrams twice a day. The drug is not recommended for  children.

Take this drug with food.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects. Side effects may include:






Rapid heart beat




Upset stomach


Inability to remain in a sitting position


Feeling of muscular quivering

Extrapyramidal symptoms


Dry mouth

Appetite loss

Muscle aches


Symptoms of overdose are:

Weak, rapid pulse


Slurring of speech Rise in blood pressure

•    Call a doctor. Apply, if necessary, cardiac massage and mouth-to-mouth breathing.


•    Do not mix this drug with other medicines that can affect the heart. Some drugs to avoid are:

•   Quinidine

•   Dofetilide

•   Pimozide

•   Sotalol

•   Thioridazine

•   Moxifloxacin

•    This drug can increase the effects of alcohol, sedatives, and other nervous system depressants.

•    Carbamazepine, phenobarbital, phenytoin, and rifampin may reduce the blood levels of this medicine.

•    Be sure to tell your doctor about any medications (also over-the-counter drugs) you are currently taking.

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.


Store at room temperature in tightly closed, light-resistant containers. Keep out of the reach of children since overdose may be especially dangerous in children.

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About Genomic Medicine UK

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