WHAT IS VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) TEST?
A vasoactive intestinal polypeptide (VIP) is a gastrointestinal hormone produced by neuroendocrine cells in the small and large intestines, pancreas, brain, and peripheral nervous system. Its actions include stimulating watery pancreatic secretions with a high pH, stimulating glycogenolysis, inhibiting stomach secretions, stimulating the release of insulin and glucagon, causing peripheral vasodilation, exhibiting a positive inotropic and chronotropic effect on the cardiovascular system, slowing gastric motility, stimulating intestinal chloride secretion, and inhibiting intestinal sodium absorption. Clients with vipoma neoplasms have symptoms of watery diarrhoea that is high in potassium and bicarbonate. VIP is also found abundantly in the human lung and is thought to cause bronchodilation.