WHAT IS VANCOMYCIN TEST?
Vancomycin is an aminoglycoside antibiotic that inhibits cell wall synthesis of gram-positive bacteria. It is frequently used in the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and in treatment for pseudomembranous colitis. Vancomycin is metabolized in the liver, with 80% excreted through the kidneys and a small amount in bile. Oral doses are primarily excreted in the faeces. Vancomycin half-life is very dependent on renal glomerular function. Rapid infusions of this drug have been associated with histamine release causing “red-man syndrome,” in which the skin becomes flushed, erythematous, and pruritic. The predictability of therapeutic effect is better at trough levels than at peak levels; thus, peak levels are not routinely recommended unless the client has renal failure or in other situations where the volume distribution is increased.