WHAT IS TENSILON TEST?
Myasthenia gravis is an autoimmune neuromuscular disease characterized by the fatigue of the limb, facial, bulbar, and ocular muscles with repetitive activity and by improvement with rest. Respiratory muscle fatigue can also occur. It is caused by circulating antibodies directed toward the skeletal muscle acetylcholine receptor. The factors that trigger the autoimmune response are unknown. In the Tensilon (edrophonium chloride) test, a short-acting anticholinesterase is administered intravenously, and muscle response is observed. The test is most useful if improvement in ptosis or the strength of an extraocular muscle is demonstrated because of the objective nature of this response. After intravenous administration of Tensilon, muscle strength will improve quickly in clients with myasthenia gravis.