WHAT IS SECRETIN TEST FOR PANCREATIC FUNCTION?
Secretin is a polypeptide secreted by the duodenal mucosa and the upper jejunum in response to gastric acidity. Some of its actions are to stimulate pancreatic enzyme secretion and bicarbonate pancreatic juice production. This test allows an assessment of pancreatic endocrine function by assessing duodenal contents for volume and bicarbonate, amylase, lipase, and trypsin levels before and after pancreatic stimulation by secretin. In chronic pancreatitis and cystic fibrosis, all values are low because of pancreatic tissue destruction. In early stages of obstructive pancreatic cancer, the volume may be low, with other values normal. In pancreatic pseudocyst, bicarbonate level may be decreased, with other values normal. This test is usually followed by magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasound (EUS), or spiral computed tomography (spiral CT) and is replacing endoscopic retrograde cholangiopancreatography for confirming the diagnosis of chronic pancreatitis.