WHAT IS SCHILLING TEST?

WHAT IS SCHILLING TEST?

The Schilling test is a vitamin B12 (cyanocobalamin) absorption test that indicates if a client lacks intrinsic factor by measuring excretion of orally administered, radiolabeled cyanocobalamin (vitamin B12) in a 24-hour urine sample. Vitamin B12 normally combines with intrinsic factor from the stomach and is absorbed in the terminal ileum. The test is based on the fact that, in normal clients, absorbed vitamin B12 in excess of the body’s needs is excreted in the urine. Because parenteral nonradiolabeled cyanocobalamin is also administered to saturate the vitamin B12 binding sites, all the radiolabeled cyanocobalamin should eventually be excreted in the urine. Because this test requires the use of radioactive cobalt and the diagnosis of pernicious anaemia can be made using other tests, the Schilling test is no longer performed and has not been available since 2003. See Pernicious Anemia in Part One for a full listing of tests used to diagnose pernicious anaemia. 

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About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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