WHAT IS RESERPINE TEST?
Reserpine, an alkaloid of the Rauwolfia serpentina and Rauwolfia vomitoria plants, is used primarily as an antihypertensive (reduces SBP), sedative, or tranquillizer. It acts at adrenergic receptor sites, primarily of the central and peripheral nervous systems and heart, by interfering with the binding of serotonin. Reserpine is metabolized in the liver and excreted as an inactive metabolite in small amounts in the urine and stool. Reserpine has a very slow onset of peak action (2-3 weeks) with a prolonged effect (4-6 weeks); thus, alterations in dosage occur in small increments and at 7- to 14-day intervals. Half-life is 4.5 hours and duration of 45-168 hours.