WHAT IS P-selectin TEST?
P-selectin is a glycoprotein that exists in two forms—a soluble protein (sP-selectin) and bound to platelets and endothelial cells—and is thought to help modulate platelet-leukocyte-endothelial activity during acute coronary syndromes and during inflammatory activity. P-selectin is thought to be a marker for platelet activation because it exists only on platelets that have undergone the release action and is involved with leukocytes on endothelial tissue, and levels increase within minutes of triggers. Levels of both the soluble and bound forms of P-selectin have been found to be elevated in clients with acute coronary syndromes, and so it is possible that P-selectin levels may serve as a coronary marker. The P-selectin profile measures both soluble and bound forms of the glycoprotein via enzyme immunoassay. While the sensitivity of this test is more than 90%, the specificity for chest pain is currently only about 55%. This is because many other noncardiac causes of chest pain also involve inflammatory processes that trigger increases in P-selectin level.