WHAT IS LIPID-ASSOCIATED SIALIC ACID (LIPID-BOUND SIALIC ACID, LASA, LSA) TEST?
Lipid-associated sialic acid (LASA) is a derivative of neuraminic acid, a widely distributed sugar that attaches itself to proteins and lipids. This lipid-associated tumour marker is found in the serum of clients with malignant disease and is associated with higher tumour burdens as opposed to low and moderate tumour burdens. Theoretically, LASA levels are believed to be increased in cancer because LASA has the ability to identify cells with altered surface properties, such as cancer cells, and bind to the surfaces, making the tumour cells more susceptible to metastasis and probable lysis by activated macrophages. LASA is also elevated after myocardial damage and is a constituent of total sialic acid, which is an independent cardiac risk factor.