WHAT IS HAM’S TEST (ACIDIFIED SERUM TEST ACID HEMOLYSIN TEST)?

WHAT IS HAM’S TEST (ACIDIFIED SERUM TEST ACID HEMOLYSIN TEST)?

For Ham’s test, a blood sample is taken from the client, mixed with his or her own serum and with a sample of serum from an ABO-compatible donor, acidified, and examined for lysis. The presence of lysis in the client’s own serum is definitive in the diagnosis of PNH. This rare condition, in which haemoglobin is found in the urine during and after sleep, is believed to be related to red blood cell hypersensitivity to higher levels of carbon dioxide and a resulting decrease in the plasma pH, though the cause of this disease is unknown. 

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