WHAT IS GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD, G-6-PD), QUANTITATIVE TEST?
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme normally present in the erythrocytes. This enzyme is part of the pentose phosphate pathway that metabolises glucose and functions to protect cells from damage by oxidising agents. This test measures G6PD levels in red blood cells, thereby detecting deficiencies of this enzyme. G6PD deficiency is a sex-linked genetic disorder found mostly in males that results in hyperbilirubinemia, jaundice, and hemolysis of erythrocytes, producing anaemia after the receipt of certain drugs. Drugs that may precipitate hemolytic episodes in affected individuals include acetanilide, acetyl phenylhydrazine, antipyrine, ascorbic acid, aspirin, chloramphenicol, nalidixic acid, naphthalene, nitrofuran, nitrofurantoin, pentaquine, phenacetin, phenylhydrazine, primaquine, probenecid, quinacrine, quinidine, quinine, sulfonamides, and vitamin K. Other precipitants include diabetic acidosis, fava bean ingestion, infections (viral, bacterial), and septicemia.