WHAT IS FETAL HEMOGLOBIN (HBF) TEST?
HbF, the haemoglobin present during fetal development, contains a polypeptide globin chain that is different from that in adult haemoglobin. It composes most of the haemoglobin of a newborn’s red blood cells. Over the first 6 months of life, most of the fetal haemoglobin is replaced by adult haemoglobin, though a small portion of HbF may persist throughout the life span. This test is most often used to differentiate thalassemia and other hemoglobinopathies in which abnormalities may be found in the polypeptide globin chains.