WHAT IS FACTOR XIII (FIBRIN-STABILIZING FACTOR, CLOT UREA SOLUBILITY) TEST?
Factor XIII is an alpha globulin that, in its active form, stabilises fibrin clots. Its deficiency is a rare, inherited, autosomal recessive condition that may result in symptoms ranging from abnormal bleeding from cuts and bleeding in joints to cerebral haemorrhage and infant death from umbilical cord haemorrhage. One performs the test by adding calcium chloride to the sample and clotting the mixture at 37 degrees C for an hour, and then placing the clot in 5 M urea and observing hourly for clot dissolution. Clots from clients with factor XIII deficiency will dissolve within 1-3 hours.