WHAT IS FACTOR XI (PLASMA THROMBOPLASTIN ANTECEDENT, PTA) TEST?

WHAT IS FACTOR XI (PLASMA THROMBOPLASTIN ANTECEDENT, PTA) TEST?

Factor XI is a betaglobulin active in stage I of the intrinsic coagulation pathway and missing, defective, or deficient in haemophilia C, an inherited, autosomal recessive deficiency that occurs in both sexes and causes prolonged coagulation evidenced by mild bleeding after surgical procedures. One performs the test by first determining the partial thromboplastin time (PTT) of the client’s plasma. A factor XIdeficient plasma substrate is then mixed with the client’s plasma, and the degree of correction in the PTT is determined and compared to the degree of correction obtained by normal plasma. 

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