WHAT IS FACTOR VII (STABLE FACTOR, PROCONVERTIN, AUTOPROTHROMBIN I) TEST?
Factor VII is a vitamin K–dependent beta globulin synthesised in the liver. It is activated in the extrinsic pathway during blood clotting and in turn activates tissue thromboplastins, with excess amounts of factor VII present in serum and plasma when clotting is completed. Both forms of the rare factor VII deficiency are autosomal recessive and affect both males and females. Bleeding symptoms may be severe, including cerebral haemorrhage. One performs the test by first determining the prothrombin time (PT) of the client’s plasma. A factorVII–deficient plasma substrate is then mixed with the client’s plasma, and the degree of correction in the PT is determined and compared to the degree of correction obtained by normal plasma.