WHAT IS FACTOR (FITZGERALD) TEST (HIGH-MOLECULAR-WEIGHT KININOGEN)?

WHAT IS FACTOR (FITZGERALD) TEST (HIGH-MOLECULAR-WEIGHT KININOGEN)?

Fitzgerald factor deficiency is a rare, autosomal recessive trait affecting the intrinsic pathway of coagulation that results in an abnormal APTT and coagulation time without other factor deficiencies. Fitzgerald factor interferes with plasminogen activation, immune pathway activation, and generation of the vasoactive polypeptide bradykinin. The client is asymptomatic for bleeding. 

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