WHAT IS CYCLIC ADENOSINE MONOPHOSPHATE PROVOCATION TEST?
A test that measures cyclic adenosine monophosphate (cAMP) response to parathyroid hormone administration. The cAMP is an enzyme that influences the rate of cell protein synthesis and indirectly affects renal reabsorption of phosphate, gastrointestinal calcium absorption, and skeletal calcium mobilisation. In normal clients and those with idiopathic or postoperative hypoparathyroidism, parathyroid hormone administration causes increased renal tubular production of cAMP. In clients with pseudohypoparathyroidism—a genetically transmitted, autosomal dominant disease resulting in tissue resistance to the effects of parathyroid hormone—the infusion fails to increase the production of cAMP in the renal tubules, resulting in a negative test.