WHAT IS CYCLIC ADENOSINE MONOPHOSPHATE PROVOCATION TEST?

WHAT IS CYCLIC ADENOSINE MONOPHOSPHATE PROVOCATION TEST?

A test that measures cyclic adenosine monophosphate (cAMP) response to parathyroid hormone administration. The cAMP is an enzyme that influences the rate of cell protein synthesis and indirectly affects renal reabsorption of phosphate, gastrointestinal calcium absorption, and skeletal calcium mobilisation. In normal clients and those with idiopathic or postoperative hypoparathyroidism, parathyroid hormone administration causes increased renal tubular production of cAMP. In clients with pseudohypoparathyroidism—a genetically transmitted, autosomal dominant disease resulting in tissue resistance to the effects of parathyroid hormone—the infusion fails to increase the production of cAMP in the renal tubules, resulting in a negative test. 

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Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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