WHAT IS CRYOGLOBULIN (QUALITATIVE) TEST?
Cryoglobulins are abnormal serum proteins that precipitate at low laboratory temperatures and redissolve after being warmed. They cannot be identified by serum protein electrophoresis. Cryoglobulin presence in the serum causes vascular problems most commonly of the extremities and is usually associated with the immunologic disease. Three types may be delineated to help differentiate the type of disease occurring. This test involves obtaining a “cryocrit” by observation for cold precipitation of cryoglobulin after at least 72 hours of storage at 4 degrees C and confirmation of the reversibility of the reaction by rewarming of the serum sample.