WHAT IS COOMBS’ TEST (DIRECT ANTIGLOBULIN TEST)?

WHAT IS COOMBS’ TEST (DIRECT ANTIGLOBULIN TEST)?

The direct Coombs’ test involves adding Coombs’ antihuman globulin serum to a client’s washed red blood cells and observing for agglutination, which signals the presence of previously undetected IgG antibodies, complement, or immunoglobulins on the surfaces of the client’s erythrocytes. The Coombs’ antiglobulin contains antibodies to IgG and several complement components. The antibodies detected by the direct Coombs’ test are difficult to detect any other way because they are left over from incomplete antigen-antibody reactions and, though present on the erythrocyte surfaces remains invisible. The Coombs’ antiglobulin causes completion of the antigen-antibody reaction, thus making the antibodies identifiable as they begin clumping. 

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About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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