What are the indications that there may be Lynch syndrome in a family?
Doctors use something called the revised Bethesda criteria to identify who should be offered testing for Lynch syndrome. Individuals meeting any of the following criteria should be offered tumour testing for Lynch syndrome:
- Colorectal cancer diagnosed before age 50 years of age.
- Colorectal cancer with a rare pathology such as tumour infiltrating lymphocytes, Crohn’s-like lymphocytic reaction, mucinous/signet-ring differentiation, or medullary growth pattern; diagnosed before age 60 years of age.
- Colorectal cancer and another Lynch syndrome associated tumour like those of the bowel, small bowel, womb, stomach, ovarian, pancreas, urinary tract, biliary tract, brain tumours, sebaceous gland adenomas and keratoacanthomas.
- Colorectal cancer and 2+ relatives with colorectal cancer at any age
- Colorectal cancer and 1 relative diagnosed with colorectal cancer before age 50