What are the cancer risks associated with a BRCA mutation?
It is important to remember that not everyone who inherits a BRCA gene mutation will develop cancer and the estimated cancer risks associated with BRCA mutations vary. BRCA1 mutations are estimated to have up to an 85% risk of breast cancer and a 40-60% risk of ovarian cancer. Men with BRCA1 mutations may have a slightly increased risk of prostate cancer and male breast cancer. Women with BRCA2 mutations have up to a 90% risk of breast cancer and up to a 26% risk of ovarian cancer. Men with BRCA2 mutations have a 5-10% lifetime risk of developing breast cancer, and an increased risk of prostate cancer (2-5 times the general population risk). Individuals with BRCA2 mutations also have an increased risk of pancreatic cancer and possibly other cancers. Occasionally, a baby will inherit two BRCA2 mutations and will therefore have the congenital condition known as Fanconi Anemia.