Cancer of the vulva is a relatively rare gynaecologic malignancy that represents less than 5% of gynaecologic cancer and is primarily seen in postmenopausal women. Like cervical cancer, the aetiology of vulvar cancer is prior infection with HPV. Patients with vulvar cancer complain of itching, pain, and local discomfort, often arising in the presence of atrophic changes of the vulvar epithelium. The treatment of vulvar cancer is surgical excision with good margins and possible dissection of one or both inguinal lymph node regions in advanced disease. Recurrent or unresectable vulvar cancer also can be treated with external beam radiation, often in combination with cisplatin in radiation sensitizing doses.