Thiothixene

Thiothixene

Properties

This medicine contains as active ingredient thiothixene, a psychoactive medicine that influences the activity of the brain. It is effective in reducing the violent aggressive manifestations of mental illnesses such as schizophrenia, mania, and other disorders in which hallucinations are experienced.

This drug is one of many non-phenothiazine agents used to treat psychosis. These drugs are equally effective when given in therapeutically equivalent doses. The major differences are in the type and severity of side effects. Some people may respond well to one and not at all to another.

Prescribed for

The drug is prescribed for:

•   Schizophrenia

•   Agitation and psychotic behavior

•   Huntington’s chorea.

•   Aggression in Alzheimer’s dementia

Before using this medicine

Before you use this medicine check with your  doctor:

•   if you ever had any unusual or allergic reaction to haloperidol.

•    if you are pregnant or intend to become pregnant while using this medicine. Decide with your doctor if the drug benefits justify the risk to the unborn child.

•    if you are breast-feeding an infant. The drug passes into the breast milk. Avoid the drug or discontinue nursing until you finish the medicine.

•   if you have suffering from a depression.

•   if you have Parkinson’s disease.

Treatment

This medication is used to relieve or prevent the symptoms of your medical problem affecting your brain  function.

Usual dose:The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regime. The usual starting dose for milder conditions is 2 mg taken three times a day. Your doctor may increase the dose to a total of 15 mg a day.

For more severe conditions the usual starting dose is 5 mg two times a day. Your doctor may increase the dose to a total of 60 mg a day. Exceeding a total daily dose of 60 mg rarely increases the beneficial  response.

Prolonged use:the patient may develop tardive dyskinesia. Talk to your doctor for follow-up medical examinations or laboratory studies to check blood pressure, liver function.

Cautions and Warnings

•   This drug should be avoided by people with:

•   Low blood pressure

•   Parkinson’s disease

•   Blood disease

•   Liver disease

•   Heart disease

•   Kidney disease

•    The drug can cause tardic dyskinesia, a serious, sometimes irreversible movement disorder that causes involuntary movements of muscles. The risk of tardive dyskinesia is higher in the elderly and for women. Tell your doctor immediately if you experience any involuntary muscle movements while taking this drug.

•    This drug can also cause another serious sometimes fatal disorder known as neurologic malignant syndrome, characterized by

•   Muscle stiffness

•   Increased body temperature

•   Sweating

•   Changes in mood

•   Changes in consciousness

•   Rapid or irregular heart beat

If you experience any of these symptoms while taking this drug, seek emergency medical attention  immediately.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects. Side effects may include:

Allergic rash

Blurred vision

Dizziness

Drowsiness

Dry mouth

Immobility

Increased heart rate

Involuntary muscle contractions

Liver damage

Low blood pressure

Menstrual irregularities

Muscle restlessness

Muscle stiffness

Muscle tremors

Blood disorders

Overdose

Symptoms of overdose are:

Weak, rapid pulse

Shallow, slow breathing

Tremor or muscle weakness

Very low blood pressure

Convulsions

Deep sleep ending in coma

•    Call a doctor. Apply, if necessary, cardiac massage and mouth-to-mouth breathing.

Interactions

•    Be cautious about taking this medicine with barbiturates, sleeping pills, narcotics or other sedatives, tricyclic depressants, alcohol, or any other medication that may produce a depressive effect.

•    It is especially important to check with your doctor before combining this medicine with the following anticholinergic medications such as:

•   Atropine

•   Antihistamines

•   Blood pressure medications

•   Carbamazepine

•   Opiates

•    Be sure to tell your doctor about any medications (also over-the-counter drugs) you are currently taking.

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.

Storage

Store at room temperature in tightly closed, light-resistant containers. Keep out of the reach of children since overdose may be especially dangerous in children.

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