Genetic predisposition to skin cancer is most frequently seen by dermatologists in a number of dominantly inherited conditions such as familial melanoma, the basal cell nevus syndrome, self-healing epitheliomas of Ferguson Smith, and Bazex–Dupré–Christol syndrome. There are also a number of rare skin diseases which are associated with chronic inflammation of the skin, such as epidermolysis bullosa which are associated with an increased risk of squamous cell carcinoma of the skin (SCC). (Tsai and Tsao 2004).
we will discuss inherited disorders where skin cancers occur but for which there are often more pressing medical implications, such as albinism, the chromosome breakage disorders (Bloom’s syndrome, Fanconi anemia, ataxia telangiectasia, xeroderma pigmentosum), Cowden’s disease, dermatitis herpetiformis/celiac disease, DiGeorge syndrome, familial hyperglucagonemia, Gardner’s syndrome, the basal cell nevus syndrome (Gorlin syndrome), hemochromatosis, multiple endocrine neoplasia type 2 (MEN2B), neurofibromatosis type 1 (NF1), porphyria, tuberose sclerosis, and tylosis.
There are some additional dermatological disorders which show some clustering in families, which may rarely be associated with skin cancer, such as lichen planus or lichen sclerosus et atrophicus, but these are not discussed here.