PANCREAS (ENDOCRINE AND EXOCRINE) MALIGNANCIES GENOMIC RISK ASSESSMENT

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Description

Description

  1. 1
    WHAT IS PANCREATIC CANCER?
    • Cancer of the pancreas refers to the growth of cancer cells in the pancreas. The pancreas is in the abdomen (belly), with the stomach, intestines, and other organs around it. It makes juices used in digestion and several hormones, including insulin, which controls blood sugar (glucose) level. It releases these substances into ducts (tubes). Pancreatic cancer starts from cells lining these ducts.
    • Almost 30,000 people in the United States are diagnosed with this cancer each year. Early detection is best for a cure, but this cancer is hard to find early because most symptoms do not occur until cancer has spread.
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    WHAT CAUSES PANCREATIC CANCER?
    • Causes are unclear, but smoking, alcoholism, and chronic inflammation (swelling) of the pancreas (pancreatitis) are related to this disease.
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    WHAT ARE THE SYMPTOMS OF PANCREATIC CANCER?
    • Because pancreatic cancer doesn’t cause symptoms early, it’s called silent. Symptoms depend on cancer’s location and size. If the bile duct is blocked so that bile cannot pass into the intestines, jaundice may occur. The skin and whites of the eyes become yellow, and urine may become dark.
    • Growing cancer causes pain in the upper abdomen and sometimes the back. Pain becomes worse after eating or lying down. Other symptoms are nausea, reduced appetite, weight loss, and weakness.
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    HOW IS PANCREATIC CANCER DIAGNOSED?
    • The doctor makes a preliminary diagnosis from symptoms and special imaging tests called computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. They help decide the stage (extent) of disease by showing whether cancer affects other organs.
    • The doctor may also order a test called endoscopic retrograde cholangiopancreatography (ERCP). This test uses dye and a flexible tube passed down the throat and into the intestine to get x-rays. The best way to diagnose cancer is with a biopsy. A piece of the pancreas is taken and checked with a microscope to detect cancer cells.
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    HOW IS PANCREATIC CANCER TREATED?
    • Surgery may be done to remove all (total pancreatectomy) or part of the pancreas and other tissues. In the Whipple procedure, the surgeon removes the head of the pancreas, parts of the small intestine and stomach, and other tissues. Sometimes cancer cannot be completely removed, but surgery can help relieve symptoms.
    • Radiotherapy and chemotherapy are also used. Radiotherapy uses high-energy rays to kill cancer cells. Chemotherapy (drugs to kill cancer cells) may be given alone or with radiotherapy if cancer cannot be removed. Doctors sometimes give chemotherapy after surgery to control cancer cell growth.
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    PANCREAS (ENDOCRINE AND EXOCRINE) MALIGNANCIES GENOMIC RISK ASSESSMENT
    • Innovative genomic DNA testing to investigate if you are at a higher risk of developing pancreas malignancy due to certain hereditary mutations in your genes.
    • This genomic test is recommended if you have a strong family history of pancreas malignancies (i.e. first-degree relative who has been diagnosed with pancreas malignancy).
    • You will be provided with a DNA assessment kit that contains all the necessary materials and instructions to have your DNA sample taken without any pain or stress.
    • You will be able to take your DNA sample in the comfort of your home (or you can get your treating GP or specialist to take it for you in the clinic). Afterwards, you can simply post the DNA sample back, in the provided prepaid envelope, to Genomic Medicine UK laboratory in London.
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    OVERVIEW

    This genomic malignancy risk assessment evaluates your DNA for the following hereditary genetic mutations that may increase your risk of developing pancreas malignancy:

    APC

    ATM

    BMPR1A

    BRCA1

    BRCA2

    CDK4

    CDKN2A

    EPCAM

    MEN1

    MLH1

    MSH2

    MSH6

    NF1

    PALB2

    PMS2

    SMAD4

    STK11

    TP53

    VHL

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    KNOWLEDGE IS POWER
    • If your results show that you are genetically predisposed to developing pancreas malignancy, your prognosis will be significantly improved by having regular malignancy screenings at shorter intervals. Please remember that the absolute majority of malignant tumours are treatable and curable when they are caught at their early stages.
    • If your test shows that you are at a higher risk of developing pancreas malignancy, this can be enormously mitigated in most of the cases by adopting a healthier lifestyle and following our malignancy prevention guidance. Please remember that genes are not a destiny book but are only a background for a multitude of different potentials.
    • It is always true that prevention is better than cure.
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    FREE REFERRAL TO A SPECIALIST CONSULTANT

    If you your genomic testing showed that you require referral to a specialist consultant, we will provide you, at no cost to you, with a referral letter to a specialist consultant from our wide network of independent doctors all around the United Kingdom. Our referral letter will give the specialist consultant all the needed details to take care of your clinical case, according to the results of the genomic tests you have had at Genomic Medicine UK.

  10. 10
    QUALITY ASSURANCE
    • This advanced genomic test is carried out by cutting-edge next-generation DNA sequencing technology at our ISO9000 certified and accredited laboratory.
    • All test results are interpreted and reported in London by our highly qualified licenced consultant medical doctors.
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    FREQUENTLY ASKED QUESTIONS
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    FURTHER INFORMATION
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    SAMPLE REPORTS
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    BY POST OR BY APPOINTMENT

    If you prefer to visit Genomic Medicine UK instead of having your genomic test by post, as explained above, you are most welcome to book a suitable appointment for you to visit our premises in central London where our fully trained and friendly staff will be more than happy to take your DNA sample in one of our outpatients’ clinics in Harley Street.

£499.00

£499.000

Innovative genomic DNA testing to investigate if you are at a higher risk of developing pancreas malignancy due to certain hereditary mutations ….

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