OESOPHAGUS MALIGNANCIES GENOMIC RISK ASSESSMENT

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SERVICE DESCRIPTION

SERVICE DESCRIPTION

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    WHAT IS OESOPHAGEAL CANCER?
    • The oesophagus is the part of the digestive tract that connects the mouth with the stomach. Oesophageal cancer is a cancerous (malignant) tumour of this tube. Most of these cancers occur in the lower part of the oesophagus. More than 10,000 new cases are diagnosed in the United States every year.
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    WHAT CAUSES OESOPHAGEAL CANCER?
    • The cause is unknown. Certain risk factors, such as heavy alcohol and tobacco use, increase the chances of getting this cancer. It isn’t contagious. Acid reflux from the stomach that occurs for a long time can lead to changes in the lining of the oesophagus (Barrett’s oesophagus), which can, in some cases, lead to Oesophageal cancer.
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    WHAT ARE THE SYMPTOMS OF OESOPHAGEAL CANCER?
    • Trouble swallowing solid foods is the usual symptom. As the tumour grows, liquids become hard to swallow, and pain with swallowing can occur. Cancer usually spreads nearby, to lungs, windpipe, lymph glands, and liver. Hoarseness, coughing, coughing up or vomiting blood, and chest pain can result.
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    HOW IS OESOPHAGEAL CANCER DIAGNOSED?
    • The best way for the doctor to make a diagnosis is with an endoscope and biopsy. With this lighted tube, passed through the mouth into the oesophagus, the doctor can get a tissue to study with a microscope. X-ray studies, a barium swallow examination or esophagography, can also be done.
    • After diagnosis, staging is needed to tell the extent of disease and whether it spread. A physical examination, blood tests, and computed tomography (CT) of the chest and abdomen are used. Spread to the voice box (larynx) is checked with laryngoscopy. Spread to the lungs may also be checked with bronchoscopy. These examinations use lighted tubes passed into the larynx or lungs.
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    HOW IS OESOPHAGEAL CANCER TREATED?
    • Therapy depends on the stage of the disease and its spread. It can include surgery, radiation, and chemotherapy (cancer-fighting drugs). In operation called esophagectomy, the surgeon removes the cancerous part of the oesophagus and lymph glands. Radiation is used instead of surgery when the tumour is too large to remove, or the person cannot undergo an operation. Chemotherapy can be used with radiation and surgery.
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    OESOPHAGUS MALIGNANCIES GENOMIC RISK ASSESSMENT
    • Innovative genomic DNA testing to investigate if you are at a higher risk of developing oesophagus malignancy due to certain hereditary mutations in your genes.
    • This genomic test is recommended if you have a strong family history of oesophagus malignancies (i.e. first-degree relative who has been diagnosed with oesophagus malignancy).
    • You will be provided with a DNA assessment kit that contains all the necessary materials and instructions to have your DNA sample taken without any pain or stress.
    • You will be able to take your DNA sample in the comfort of your home (or you can get your treating GP or specialist to take it for you in the clinic). Afterwards, you can simply post the DNA sample back, in the provided prepaid envelope, to Genomic Medicine UK laboratory in London.
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    OVERVIEW

    This genomic malignancy risk assessment evaluates your DNA for the following hereditary genetic mutations that may increase your risk of developing oesophagus malignancy:

    FANCA

    FANCB

    FANCC

    FANCD2

    FANCE

    FANCF

    FANCG

    FANCI

    FANCL

    FANCM

    RHBDF2

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    KNOWLEDGE IS POWER
    • If your results show that you are genetically predisposed to developing oesophagus malignancy, your prognosis will be significantly improved by having regular malignancy screenings at shorter intervals. Please remember that the absolute majority of malignant tumours are treatable and curable when they are caught at their early stages.
    • If your test shows that you are at a higher risk of developing oesophagus malignancy, this can be enormously mitigated in most of the cases by adopting a healthier lifestyle and following our malignancy prevention guidance. Please remember that genes are not a destiny book but are only a background for a multitude of different potentials.
    • It is always true that prevention is better than cure.
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    FREE REFERRAL TO A SPECIALIST CONSULTANT

    If you your genomic testing showed that you require referral to a specialist consultant, we will provide you, at no cost to you, with a referral letter to a specialist consultant from our wide network of independent doctors all around the United Kingdom. Our referral letter will give the specialist consultant all the needed details to take care of your clinical case, according to the results of the genomic tests you have had at Genomic Medicine UK.

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    QUALITY ASSURANCE
    • This advanced genomic test is carried out by cutting-edge next-generation DNA sequencing technology at our ISO9000 certified and accredited laboratory.
    • All test results are interpreted and reported in London by our highly qualified licenced consultant medical doctors.
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    FREQUENTLY ASKED QUESTIONS
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    FURTHER INFORMATION
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    SAMPLE REPORTS
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    BY POST OR BY APPOINTMENT

    If you prefer to visit Genomic Medicine UK instead of having your genomic test by post, as explained above, you are most welcome to book a suitable appointment for you to visit our premises in central London where our fully trained and friendly staff will be more than happy to take your DNA sample in one of our outpatients’ clinics in Harley Street.

£499.00

£499.000

Innovative genomic DNA testing to investigate if you are at a higher risk of developing oesophagus malignancy due to certain hereditary mutations …

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