COLON AND RECTUM MALIGNANCIES GENOMIC RISK ASSESSMENT

ASK US A QUESTION





Please prove you are human by selecting the Plane.

SERVICE DESCRIPTION

SERVICE DESCRIPTION

  1. 1
    WHAT IS THE COLON?
    • The colon is part of the digestive system. Food moves from the mouth to the stomach. Several hours later, it moves into the intestines, first the small intestine and then the large intestine. After digestion of food is finished, what’s left leaves the body as waste (stool) through the rectum. The colon is the last part of the large intestine, just before the rectum.
  2. 2
    WHAT IS COLON CANCER?
    • Colon cancer is a tumour in the colon. It is the most common cancer of the digestive tract. Other names are adenocarcinoma of the colon and colorectal cancer (often the lower rectum and sigmoid part of the colon are involved). Cancer can also be found in the first part of the colon (cecum). Colon cancer can also spread (metastasise) to other parts of the body.
    • Colon cancer usually starts as a small growth (polyp) on the surface of the colon. Some polyps are harmless, but some can turn into cancer.
    • Colon cancer tends to run in families. If you have a strong family history of colon cancer, you should discuss with your doctor genetic testing done with blood tests to look for genetic changes that predispose to rare hereditary colon cancers known as familial adenomatous polyposis (FAP) and Lynch syndrome.
  3. 3
    WHAT ARE THE SYMPTOMS OF COLON CANCER?
    • Symptoms to be aware of are a change in bowel habits, such as constipation or diarrhoea, a change in stool size (e.g., pencil-thin) or stool appearance (e.g., black and tarry), rectal bleeding, and abdominal pain.
    • Sometimes no symptoms are present, but iron deficiency anaemia from long-term blood loss may occur.
    • Early diagnosis is critical because undetected or untreated cancer usually spreads through the intestine wall into neighbouring areas and into the liver. Sometimes it can also spread to lungs and bones.
  4. 4
    HOW IS COLON CANCER DIAGNOSED?
    • The doctor will do a complete physical examination, including a digital rectal examination (DRE), and take one or more stool samples. These samples are analysed for any occult (hidden) blood. This testing can find bleeding in the intestine, but results can be inaccurate because certain medicines or red meat may produce positive results that are normal (false-positive results).
    • The doctor also looks inside the colon with a flexible tube called a colonoscope. This scope is passed through the rectum to see the whole colon. The doctor can see problem areas and biopsy (take samples of) these areas and remove any polyps. The samples are studied under a microscope to look for cancerous cells. Other tests, such as computed tomography (CT), of the abdomen and pelvis may be done to see whether cancer has moved to other parts of the body.
    • A newer screening test involves using CT only for the intestine (CT colonography). This test is also called virtual colonoscopy. For this test, compressed air is pumped into your rectum through a tube, and then a picture is taken of your colon. For this test, you will also have to take laxatives the day before to clean out the colon. Any possible problem areas found by CT colonography will need a follow-up colonoscopy to see whether they are cancerous.
  5. 5
    RECOMMENDED REFERRAL CRITERIA FOR COLORECTAL CANCER

    Genetic testing should be discussed with patients who have been diagnosed with colorectal cancer AND meet one of the following criteria:

    • Abnormal tumour testing (MSIH or absent IHC)
    • Diagnosed < age 50
    • Diagnosed < age 60 AND TILS, signet ring formation or mucinous
    • Endometrial / ovarian cancer
    • Multiple bowel polyps
    • 2+ relatives with colorectal cancer / endometrial or ovarian cancer

    OR

    • Personal history of multiple Adenomas (10+)
  6. 6
    COLON AND RECTUM MALIGNANCIES GENOMIC RISK ASSESSMENT
    • Innovative genomic DNA testing to investigate if you are at a higher risk of developing colon and rectum malignancy due to certain hereditary mutations in your genes.
    • This genomic test is recommended if you have a strong family history of colon and rectum malignancies (i.e. first-degree relative who has been diagnosed with colon and rectum malignancy).
    • You will be provided with a DNA assessment kit that contains all the necessary materials and instructions to have your DNA sample taken without any pain or stress.
    • You will be able to take your DNA sample in the comfort of your home (or you can get your treating GP or specialist to take it for you in the clinic). Afterwards, you can simply post the DNA sample back, in the provided prepaid envelope, to Genomic Medicine UK laboratory in London.
  7. 7
    OVERVIEW

    This genomic malignancy risk assessment evaluates your DNA for the following hereditary genetic mutations that may increase your risk of developing colon and rectum malignancy:

    APC

    BLM

    BMPR1A

    CDH1

    CHEK2

    EPCAM

    KIT

    MLH1

    MSH2

    MSH6

    MUTYH

    PMS1

    PMS2

    PTEN

    SMAD4

    STK11

    TP53

  8. 8
    KNOWLEDGE IS POWER
    • If your results show that you are genetically predisposed to developing colon and rectum malignancy, your prognosis will be significantly improved by having regular malignancy screenings at shorter intervals. Please remember that the absolute majority of malignant tumours are treatable and curable when they are caught at their early stages.
    • If your test shows that you are at a higher risk of developing colon and rectum malignancy, this can be enormously mitigated in most of the cases by adopting a healthier lifestyle and following our malignancy prevention guidance. Please remember that genes are not a destiny book but are only a background for a multitude of different potentials.
    • It is always true that prevention is better than cure.
  9. 9
    FREE REFERRAL TO A SPECIALIST CONSULTANT

    If you your genomic testing showed that you require referral to a specialist consultant, we will provide you, at no cost to you, with a referral letter to a specialist consultant from our wide network of independent doctors all around the United Kingdom. Our referral letter will give the specialist consultant all the needed details to take care of your clinical case, according to the results of the genomic tests you have had at Genomic Medicine UK.

  10. 10
    QUALITY ASSURANCE
    • This advanced genomic test is carried out by cutting-edge next-generation DNA sequencing technology at our ISO9000 certified and accredited laboratory.
    • All test results are interpreted and reported in London by our highly qualified licenced consultant medical doctors.
  11. 11
    FREQUENTLY ASKED QUESTIONS
  12. 12
    FURTHER INFORMATION
  13. 13
    SAMPLE REPORTS
  14. 14
    BY POST OR BY APPOINTMENT

    If you prefer to visit Genomic Medicine UK instead of having your genomic test by post, as explained above, you are most welcome to book a suitable appointment for you to visit our premises in central London where our fully trained and friendly staff will be more than happy to take your DNA sample in one of our outpatients’ clinics in Harley Street.

£499.00

£499.000

Innovative genomic DNA testing to investigate if you are at a higher risk of developing colon and rectum malignancy due to certain hereditary mutations in your genes.

X