BREAST MALIGNANCIES GENOMIC RISK ASSESSMENT

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Description

Description

  1. 1
    WHAT IS BREAST CANCER?
    • Breast cancer is the abnormal growth of cells in the breast (ducts, lobules, or other tissues). It is the most common cancer in women in the United States. It is the second most common cause of cancer-related death in women and the main cause of death in women aged 45 to 55. Each year, about 200,000 American women are diagnosed with breast cancer, and more than 40,000 dies of this disease. Breast cancer occurs 100 times more often in women than in men.
    • Even though the number of new cases of breast cancer is rising, the death rate dropped about 20% in the past 20 years. This drop is partly because increased screening catches the disease earlier, so chances of recovery are higher.
    • Women with a strong family history of breast or ovarian cancer should talk with the doctor about whether blood testing for familial breast cancer is a good idea to check for genes called BRCA1 and BRCA2.
    • A higher risk of breast cancer may be related to, among other factors, having previous breast cancer, age (especially older than 50), the first menstrual period at a young age (12 or younger), menopause (when periods stopped) after age 55, and taking high-dose estrogen after menopause.
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    WHAT ARE THE SYMPTOMS OF BREAST CANCER?

    Early breast cancer usually does not cause pain and may cause no symptoms. About 10% of people have no pain or lumps or any other sign of a problem with the breasts.

    A growing breast tumour, however, can cause changes that both women and men should watch for:

    • A lump or thickening (mass, swelling, skin irritation, or distortion) in or near the breast or under the arms
    • A change in breast size or shape
    • A change in colour or feel of the skin of the breast, areola, or nipple (dimpled, puckered, or scaly)
    • Nipple discharge, erosion, inversion, or tenderness
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    HOW IS BREAST CANCER DIAGNOSED?
    • In many cases, a woman or her doctor feels a lump or discovers a change in the breast.
    • The doctor often suspects breast cancer because of an abnormal mammogram (a low-dose x-ray of breasts). Some women at high risk of developing breast cancer now have magnetic resonance imaging (MRI) to screen for it, in addition to mammograms.
    • A lump should not be ignored, even if mammogram results are normal. A mammogram doesn’t show up to 20% of new breast cancers.
    • If cancer is suspected, the next step is to confirm the diagnosis by taking a biopsy or removing a small piece of the abnormal area, for study. The biopsy may be done in the office.
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    RECOMMENDED REFERRAL CRITERIA FOR BREAST CANCER
    • Any woman concerned about her family history should be referred for a comprehensive risk assessment, and screening recommendations.
    • Genetic testing should be discussed with patients who have been diagnosed with breast cancer AND meet one of the following criteria:
      • Jewish Ancestry
      • Diagnosed < age 45
      • Bilateral breast cancer < age 60
      • Triple negative tumour
      • Ovarian cancer
      • Male breast cancer
      • Parent/child or sibling meeting above criteria
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    BREAST MALIGNANCIES GENOMIC RISK ASSESSMENT
    • Innovative genomic DNA testing to investigate if you are at a higher risk of developing breast malignancy due to certain hereditary mutations in your genes.
    • This genomic test is recommended if you have a strong family history of breast malignancies (i.e. first-degree relative who has been diagnosed with breast malignancy).
    • You will be provided with a DNA assessment kit that contains all the necessary materials and instructions to have your DNA sample taken without any pain or stress.
    • You will be able to take your DNA sample in the comfort of your home (or you can get your treating GP or specialist to take it for you in the clinic). Afterwards, you can simply post the DNA sample back, in the provided prepaid envelope, to Genomic Medicine UK laboratory in London.
  6. 6
    OVERVIEW

    This genomic malignancy risk assessment evaluates your DNA for the following hereditary genetic mutations that may increase your risk of developing breast malignancy:

    ATM

    BARD1

    BRCA1

    BRCA2

    BRIP1

    CDH1

    CHEK2

    NBN

    NF1

    PALB2

    PPM1D

    PTEN

    RAD51C

    STK11

    TP53

  7. 7
    KNOWLEDGE IS POWER
    • If your results show that you are genetically predisposed to developing breast malignancy, your prognosis will be significantly improved by having regular malignancy screenings at shorter intervals. Please remember that the absolute majority of malignant tumours are treatable and curable when they are caught at their early stages.
    • If your test shows that you are at a higher risk of developing breast malignancy, this can be enormously mitigated in most of the cases by adopting a healthier lifestyle and following our malignancy prevention guidance. Please remember that genes are not a destiny book but are only a background for a multitude of different potentials.
    • It is always true that prevention is better than cure.
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    FREE REFERRAL TO A SPECIALIST CONSULTANT

    If you your genomic testing showed that you require referral to a specialist consultant, we will provide you, at no cost to you, with a referral letter to a specialist consultant from our wide network of independent doctors all around the United Kingdom. Our referral letter will give the specialist consultant all the needed details to take care of your clinical case, according to the results of the genomic tests you have had at Genomic Medicine UK.

  9. 9
    QUALITY ASSURANCE
    • This advanced genomic test is carried out by cutting-edge next-generation DNA sequencing technology at our ISO9000 certified and accredited laboratory.
    • All test results are interpreted and reported in London by our highly qualified licenced consultant medical doctors.
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    FREQUENTLY ASKED QUESTIONS
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    FURTHER INFORMATION
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    SAMPLE REPORTS
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    BY POST OR BY APPOINTMENT

    If you prefer to visit Genomic Medicine UK instead of having your genomic test by post, as explained above, you are most welcome to book a suitable appointment for you to visit our premises in central London where our fully trained and friendly staff will be more than happy to take your DNA sample in one of our outpatients’ clinics in Harley Street.

£499.00

£499.000

Innovative genomic DNA testing to investigate if you are at a higher risk of developing breast malignancy due to certain hereditary mutations in your genes.

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