PILOMATRIXOMA (BENIGN CALCIFYING EPITHELIOMA OF MALHERBE)
Pilomatrixomas appear in young adults, most commonly on the arms, face, and neck, as asymptomatic, firm, lobular, bluish nodules, which may be painful and occasionally inflamed. They are usually sporadic but have rarely been found to occur in families. They occur in both sexes, possibly with autosomal dominant inheritance. Multiple calcifying epitheliomas have been reported in association with myotonic dystrophy (Harper 1972; Hubbard and Whittaker 2004) and with Rubinstein–Taybi syndrome (Masuno et al. 1998). A ctivating mutations in CTNNBI are detected in a high proportion of Tumours (Chan et al. 1999).