PANCREATIC CYSTS AND TUMOURS
Pancreatic cysts and Tumours are relatively common features of VHL disease. Multiple cysts are the most frequent pancreatic manifestation and are present in most older patients. However pancreatic cysts rarely impair pancreatic function. Pancreatic Tumours occur in ~10 % of cases. A high frequency of that malignancy has been reported in VHL-associated islet cell Tumours, and surgery is indicated in Tumours with a diameter of 3 cm or more (Libutti et al. 1998).