Molindone

Molindone

Properties

This medicine contains as active ingredient molindone, a family   of medicines used to treat nervous, mental, and emotional conditions.

It is thought that some forms of mental illness are caused by an increase of communication between nerve cells due to overactivity of one of more chemical messengers or neurotransmitters; in most cases of psychosis the activity level of one or more of these neurotransmitters is disregulated, but other chemical messengers, such as noradrenaline, may also show variations in their activity level.

Because a person with a psychotic illness may recover spontaneously, a drug will not always be prescribed immediately. Long-term treatment is only started when normal life is seriously interfered with. Antipsychotic drugs do not cure the underlying disorder, but they can restore normal behavior.

The drug given to a particular individual depends on the nature of his or her illness and the side effects experienced. Drugs differ in the amount of sedation that they produce; the need for sedation also influences the choice.

Prescribed for

This medicine is prescribed for:

•   Psychotic disorders

•   Schizophrenia

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

•   if you ever had any unusual or allergic reaction to any of its ingredients.

•    if you are on a low-salt, low-sugar, or any other special diet, or if you are allergic to any substance, such as sulfites or other preservatives or dyes.

•   if you are pregnant or intend to become pregnant while using this medicine. Although these medicines have not been shown to cause birth defects, some side effects such as jaundice and muscle tremors have occurred in a few newborns whose mothers received these medicines during  pregnancy.

•    if you are breast-feeding an infant. Although this medicine has not been shown to cause problems in humans the chance does exist since some of these medicines are known to pass into the breast milk.

•    if you have any of the following medical problems:

Alcoholism

Blood disease

Difficult urination

Enlarged prostate

Glaucoma

Heart or blood vessel disease

Liver or lung disease

Parkinson’s disease

Stomach ulcers

Cautions and Warnings

•    Do not take this drug if you are allergic or sensitive to any of its ingredients.

•    This drug can cause tardive dyskinesia, a serious sometimes irreversible movement disorder that causes involuntary movements of muscles. The risk for tardive dyskinesia is higher in the elderly and for women. Tel your doctor immediately if you experience any involuntary muscle movements while taking this medicine.

•    This medicine can also cause another serious, sometimes fatal, disorder known as neuroleptic malignant syndrome, characterized by:

•   Increased body temperature

•   Sweating

•   Changes in mood

•   Changes in consciousness

•   Rapid or irregular heart beat

If you experience any of these symptoms while taking this drug, seek emergency medical attention  immediately.

•    This drug is not to be used with other agents that cause central nervous system depression, such as alcohol, barbiturates, or narcotic pain killers.

•    This medicine should not be used in elderly patients with dementia- related psychosis, since this puts them at increased risk of serious side effects.

Treatment

•    This medication is prescribed to treat the symptoms of certain types of mental illness or emotional problems.

•    Usual dosage The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regime.

Adults and children 12 years and older: The usual starting dose is 50 to 75 milligrams per day. Your doctor may increase your dose to 100 mg after 3-4 days of treatment. Based on your individual condition, your dose may be further increased up to 225 mg per day. The dose is usually divided in  three to four intervals.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects. Side effects are:

Immobility

Body discomfort Fatigue

Muscle contractions

Involuntary muscle movements

Dizziness

Drowsiness

Dry mouth

Sleepiness

Restlessness

Insomnia

Muscle stiffness

Muscle tremors

•    Tell your doctor about any side effects that are persistent or particularly bothersome.

Interactions

This medicine may interact with several other drugs such as  barbiturates, sleeping pills, narcotics, other tranquillizers, or any other medication that may produce a sedative effect. Avoid  alcohol.

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.

Overdosage

Overdose  symptoms include:

•   Depression

•   Extreme weakness

•   Tiredness

•   Lowered blood pressure

•   Agitation

•   Restlessness

•   Uncontrolled muscle spasms

The victim should be taken to a hospital emergency room immediately.

Storage

Store this medication as directed on the label. Keep out of the reach of children.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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