This medicine contains trandolapril as active ingredient. It belongs to the class of medicines called angiotensin-converting enzyme (ACE) inhibitors. The drug works by relaxing the muscles around blood vessels, allowing them to dilate and thereby easing blood flow.
The ACE inhibitors are powerful vasodilators. They act by blocking the action of an enzyme that is responsible for converting a chemical called angiotensin I into angiotensin II. Angiotensin II encourages constriction of the blood vessels, and the absence permits them to dilate.
The medicine is prescribed for:
• Treatment of high blood pressure and congestive heart failure.
• Treatment for kidney disease in diabetic patients.
• Treatment of acute myocardial infarction within 24 hours of occurrence.
Before using this medicine
Before you use this medicine check with your doctor, or pharmacist:
• if you ever had any unusual or allergic reaction to ACE inhibitors
• if you are pregnant or intend to become pregnant while using this medicine
• if you have had a stroke
• if you have long-term liver problems
• if you have long-term kidney problems
• if you have coronary artery disease
• if you are breast-feeding an infant
This medication is used for treatment of high blood pressure and cardiac conditions such as heart failure.
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Adult: 1 mg a day, may be increased to 8 mg a day.
Tablets should be taken with liquid. Instructions to take on empty stomach mean 1 hour before or 2 hours after eating. Take the medicine at the same times each day, usually 2-3 times daily. Take first dose at bedtime and lie down immediately.
For safe and effective use of medicine:
Follow your doctor’s instructions if this medicine was prescribed.
Follow the manufacturer’s package directions if you are treating yourself.
Along with the needed effects, a medicine may cause some unwanted effects. Possible side effects include:
• Intense itching
• Loss of taste
• Chest pain
• Irregular heartbeat
• Numbness in hands and feet
• Tingling in hands and feet
• Nausea and vomiting
The following symptoms may be a sign of overdose:
• Fever and chills
• Blood pressure drop
• Sore throat
• Convulsions and coma
Call a doctor or hospital emergency room for instructions. If necessary start first aid immediately.
The effect of this medicine may cause a blood pressure drop if taken together with antihypertensives or beta-adrenergic blocking agents.
Interactions may also occur with non-steroidal anti-inflammatory drugs, potassium supplements, lithium and vasodilators.
Be sure to tell your doctor about any medications you are currently taking.
Driving and hazardous work
Do not drive a car until you learn how this medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes.
Tablets should be stored at in a tightly closed container in a cool, dry place; store away from heat and direct light. Keep out of reach of children, since this medicine may be dangerous in children.