This medicine contains cholestyramine as active ingredient. It is a a resin that binds bile acids in the intestine, preventing their reabsorption. Cholesterol in the body is normally converted to bile acids. Therefore, the use of this medicine results in a reduction of cholesterol in the blood. The medicine works entirely within the bowel and is never absorbed into the bloodstream. Though usually given 3-4 times a day, there appears to be no advantage to taking it more often than twice a day.
The medicine is prescribed for:
• Removal of excess bile acids that occur with some liver problems
• Lowering of cholesterol levels
Cautions and Warnings
This medicine interferes with the absorption of virtually all oral drugs, including acetaminophen, amiodarone, aspirin, clindamycin, contraceptive drugs, thiazide diuretics, etc.
Before using this medicine
Before you use this medicine check with your doctor, or pharmacist:
• if you ever had any unusual or allergic reaction to this medication
• if you are pregnant or intend to become pregnant while using this medicine
• if you are breast-feeding an infant; no problem expected, but consult your doctor
• if you have angina, heart or blood-vessel disease
• if you have a liver disorder, characterized by jaundice
• if you have stomach problems (including ulcer)
• if you have constipation or hemorrhoids
• if you have kidney disease.
This medication is used for treatment of high cholesterol levels or excess bile acids. The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor’s approval.
Powder, granules: sprinkle into 8 oz. liquid. Let stand for 2 minutes, then mix with liquid before swallowing. Or mix with cereal, soup or pulpy fruit.
When to take: 3 or 4 times a day on an empty stomach, 1 hour before or 2 hours after eating.
Children: the drug is not recommended for children under 6 years.
Diet: a low-fat, low-calorie diet may be advised for patients who are overweight.
Along with the needed effects, a medicine may cause some unwanted effects. Possible side effects include:
• Mild nausea
• Stomach pain
• Black, tarry stool
• Sore tongue
Increased side effects and adverse reactions are a sign of overdose. An overdose is unlikely to threaten life.
Call a doctor or hospital emergency room for instructions.
This medicine reduces the body’s ability to absorb other drugs. The dosage of other drugs may need to be adjusted. Possible interaction with other drugs may occur: systemic adrenocorticoids, oral anticoagulants, digitalis preparations, thiazides, vitamins.
Be sure to tell your doctor about any medications you are currently taking.
Driving or hazardous work
No problems expected.
Powder, granules should be stored at room temperature; store away from heat and direct light. Keep out of reach of children, since overdose may be dangerous in children.