LICHEN SCLEROSIS ET ATROPHICUS
This dermatological disorder is much more common in females than in males (10:1), has a predilection for the vulva, particularly in postmenopausal women, and is the most commonly encountered vulvar dystrophy.
Extragenital lesions are most common on the trunk, arms, neck, and face. The lesions are greyish, polygonal, flat papules, which may coalesce into plaques which atrophy. The vulvar lesions predispose to carcinoma of the vulva, with a reported incidence of up to 10 % of affected adult women. The lesions show elevated p53 levels and 17p loss of heterozygosity (LOH). Several cases of familial lichen sclerosis with more than one affected generation have been described, including premenopausal women and children, but these are very rare (Shirer and Ray 1987; Carlson et al. 1998).