JUVENILE HYALINE FIBROMATOSIS
This is an autosomal recessive condition characterized by multiple subcutaneous scalps. The Tumours may be disfiguring, and there is associated gingival hyperplasia. Joint contractures and osteolytic bony lesions often occur. Excision of the Tumours may be followed by recurrence (Fayad et al. 1987; Katagiri et al. 1996). The gene for this condition maps to 4q21, and mutations in CMG2 (capillary morphogenesis gene-2) appear to cause both juvenile hyaline fibrosis and infantile systemic hyalinosis (Rahman et al. 2002; Paller et al. 2003).