This medicine contains isosorbide dinitrate as active ingredient. Nitrates improve the supply of blood and oxygen to the heart. This medication is for oral use. This medication is used to treat and prevent angina (chest pain). The drug is a vasodilator, which relaxes the muscles of the blood vessels, causing an increase in the oxygen supply to the heart. The  oral tablets, capsules, ointment and patches do not act quickly; they are used to prevent chest pain. The sublingual tablets and oral spray act quickly   and can be used to relieve chest pain after it has started.

Prescribed for

This medicine is prescribed for:

•   Prevention and treatment of angina

•   Congestive heart failure

Cautions and Warnings

This drug may be inappropriate for you if you have had a recent heart attack or have severe anemia, severe kidney or liver disease.

Do not self-medicate with over-the-counter appetite suppressants and cough, cold, and allergy remedies, since many contain ingredients that may aggravate heart disease.

Taking this drug with large amounts of alcohol may rapidly lower blood pressure, resulting in weakness, dizziness, and fainting.

Before using this medicine

Before you use this medicine check with your doctor, or pharmacist:

•   if you ever had any unusual or allergic reaction to nitrates or nitrites

•    if you are on a low-salt, low-sugar, or any other special diet, or if you are allergic to any substance, such as sulfites or other preservatives or dyes

•    if you are pregnant or intend to become pregnant while using this medicine. Although nitrates have not been shown to cause problems in humans, the chance always exists

•   if you are breast-feeding an infant

•   if you have any of the following medical problems:

•   Anemia

•   Glaucoma

•   Intestinal problems

•   Overactive thyroid


Take this medicine only as much as is necessary to control chest pain. Take this medicine exactly as directed by your doctor or pharmacist. It will work only if taken correctly.

Usual dosage

Adult: Starting dosage: 5-20 mg 2-3 times a day. The maintenance dose is 10-40 mg every 6 hours. For sustained-release tablets is the starting dose 40 mg and the maintenance dose 40-80 mg every 8-12 hours. Sublingual tablets: starting dosage 2.5-5 mg, the dose may be increased gradually until angina is relieved. All dosing should include a daily dose-free interval of at least 14 hours to prevent the development of drug  tolerance.

If you are taking this medicine regularly and you miss a dose, take it as soon as possible. However, if your next scheduled dose; is within 2  hours (or within 6 hours for extended-release capsules or tablets), skip the missed dose and go back to your regular dosing  schedule.

If you have been taking this medicine regularly for several weeks or more, do not suddenly stop using it. Stopping suddenly may bring on attacks of angina.

Side effects

There are a number of side effects that usually do not require medical attention. These possible side effects may go away during treatment; however, if they continue or are bothersome, check with your doctor, nurse, or pharmacist. More common are:

•   Dizziness

•   Lightheadedness

•   Fainting when standing up

•   Fast pulse

•   Flushing of face and neck

•   Headache

•   Nausea or vomiting

Side effects that should be reported to your doctor are:

•   Blurred vision

•   Dry mouth

•   Severe or prolonged headache

•   Skin rash


This medicine may interact with several other drugs such as tricyclic antidepressants and cough medicines. Before starting to take or apply this medication, be sure to tell your doctor about any medications you are currently taking.

Check with your doctor or pharmacist if you are now taking any of the following medicines or types of  medicines:

•   Antihypertensives

•   Asthma or hay fever medicine

•   Cold medicine

•   Decongestant

•   Medicine for appetite control

•   Narcotic

•   Pain medicine

•   Sinus congestion medicine


Tablets, capsules, and oral spray should be stored as in a tightly capped bottle in a cool, dry place. Ointment and patches should be stored at room temperature in their original containers. Keep out of reach of children. Do not keep outdated medicine or medicine no longer needed.

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