What are the types of inflammation in the body?
- A rapid, non-specific response to cellular injury.
- Orchestrated by cytokines released from injured cells, e.g. histamine, serotonin, prostaglandins, leukotrienes, and platelet-activating factor.
- Cytokines activate endothelial cells, leading to the formation of an acute inflammatory exudate containing fluid, fibrin, and neutrophils.
- Severe acute inflammation may lead to a localized collection of pus within a necrotic cavity (abscess).
- Acute inflammation may resolve, heal with scarring, or progress to chronic inflammation.
- Persistent form of inflammation in which there is simultaneous tissue damage and attempted repair.
- May arise from acute inflammation or occur from the outset.
- Characterized by the presence of chronic inflammatory cells, namely macrophages, lymphocytes, and plasma cells.
- More likely to heal with irreversible scarring than resolve.
- A special type of chronic inflammation characterized by the presence of activated macrophages known as epithelioid histiocytes.
- Collections of epithelioid macrophages are known as granulomas.
- Granulomatous inflammation is associated with foreign bodies, persistent infections (e.g. mycobacteria), and diseases whose cause is unclear (e.g. sarcoidosis).