HOW DEEPLY CAN A PERSON BE ANALYZED?
Studies have been initiated to analyze people as deeply as possible to follow how their biochemical composition dynamically changes during periods of health and disease. The first of these studies analyzed the author very deeply by following his transcriptome, proteome, metabolome, cytokines, antibody reactivity, and more recently their DNA methylation patterns and microbiome, resulting in billions of measurements (Figure 1). These studies revealed the dramatic changes that occur during healthy and disease periods and the types of biochemical pathways that change. By extending these “personal omics profiles” to the study of others it is now clear that each of us has a unique biochemical profile, and the manner in which people respond to environmental situations can be quite distinct. Such information will help guide people’s health by predicting disease and catching adverse events early and on an individual basis.
Figure 1. Personal omics profiling. It is now possible to analyze people very deeply and make billions of measurements of the different biomolecules present in their blood and urine as well as their microbiome. Activity and physiology can be measured using wearable devices (sensors). By following these over time, we can observe the detailed changes that occur when people acquire disease.