Galantamine

Galantamine

Properties

This psychoactive medicine contains galantamine as active ingredient. It belongs to the group of cholinesterase inhibitors. These drugs work by increasing the function of certain receptors in the brain that are stimulated by the neurotransmitter acetylcholine. They do this by interfering with cholinesterase, the enzyme that breaks down acetylcholine. Most people with dementia (including Alzheimer’s disease) develop a shortage of this brain chemical early in the disease.

Prescribed for

The drug is prescribed for:

•   Dementia

•   Alzheimer’s disease

•   Lewy body dementia

•   Vascular dementia

•   Dementia associated with Parkinson’s disease

•   Poststroke aphasia

•   Improvement of memory in multiple sclerosis

There is no evidence that cholinesterase inhibitors reverse the degenerative effects of dementia, but they may slow the rate at which the disease worsens.

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

•    if you ever had any unusual or allergic reaction to any psychoactive medicine;

•   if you have a heart disease;

•   if you have a gastric ulcer of stomach bleeding;

•   if you have liver problems;

•   if you have kidney insufficiency.

Treatment

Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer period of time than your doctor ordered.

Dosage:The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen.

The usual starting dose is 8-32 mg once a day divided into two doses, for at least 4 to 6 weeks. Do not increase the dose during this period unless directed. The doctor may then increase the dose if response to the drug warrants it.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects.

•    Common side effects include:

Headache

General pain

Accidents

Nausea

Diarrhea

Sleeplessness

Dizziness

Tiredness

Vomiting

Appetite loss

Muscle cramps

•    Less common and rare side effects include:

Arthritis

Depression

Abnormal dreams

Fainting

Black-and-blue marks

Weight loss

•   Contact your doctor if you experience any side effects not listed above.

Warnings and Cautions

•    People with heart disease should use this medicine with caution  because it may slow heart rate and cause fainting.

•    The medicine may be expected to cause increased stomach acid and increased activity of the gastrointestinal tract. Possible complications include ulcers and bleeding. Alcohol may worsen this effect.

•    Using this medicine may also lead to urinary blockage, increase the risk of generalized seizures, and worsen asthma or other pulmonary diseases. Use with caution if you have these conditions.

•   People with severe liver disease should not take this medicine.

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.

Interactions

This medicine can be expected to increase the effects of:

•   Cevimeline

•   Surgical anesthetic drugs

•   Drugs that irritate the stomach and intestines

•   Aspirin

•   Ibuprofen

The breakdown of this medicine in the liver can be slowed by:

•   Ketoconazole

•   Itraconazole

•   Quinidine

•   Ritonavir

•   Cimetidine

•   Ciprofloxacin

•   Diltiazem

•   Erythromycin

•   Fluconazole

•   Clomipramine

•   Fluoxetine

•   Haloperidol

•   Paroxetine

•   Ranitidine

•    Be sure to tell your doctor about any medications you are currently taking.

Overdosage

An overdose of this medicine can be very serious. Symptoms include:

•   Severe nausea

•   Vomiting

•   Salivation

•   Sweating

•   Slow heart rate

•   Low blood pressure

•   Slow breathing rate

•   Convulsions

•   Muscle weakness

•   Collapse

Take the overdose victim to a hospital emergency room at once. Always bring the prescription bottle or  container.

Storage

Tablets, capsules, etc. should be stored at room temperature in tightly closed, light-resistant containers as directed by your pharmacist. Keep out of reach of children since overdose is especially dangerous in young children. Do not store in the bathroom medicine cabinet because the heat or moisture may cause the medicine to break down. Keep the liquid form of the medicine from freezing.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

Leave a Reply

Your email address will not be published. Required fields are marked *

X