Flurazepam

Flurazepam

Properties

This medicine contains as active ingredient flurazepam, a benzodiazepine preparation. Benzodiazepines belong to the group of psychoactive medicines that influence the activity of the brain.

Benzodiazepines work by a direct effect on the brain. They make it easier to go to sleep and decrease the number of times you wake up during the night. This medicine remains in the bloodstream longer than any other drug in this class, this resulting in the greatest incidence of morning “hangover.”

Prescribed for

This medicine is prescribed for insomnia and sleep  disturbances.

Before using this medicine

Before you use this medicine check with your  doctor:

•   if you ever had any unusual or allergic reaction to benzodiazepines.

•    if you are on a low-salt, low-sugar, or any other special diet, or if you are allergic to any substance, such as sulfites or other preservatives or dyes.

•    if you are pregnant or intend to become pregnant while using this medicine. Some benzodiazepines have been reported to increase the chance of birth defects when used during the first 3 months of pregnancy.

•    if you are breast-feeding an infant. Benzodiazepines may pass into the breast milk and cause drowsiness, unusually slow heartbeat, shortness of breath, or troubled breathing in infants of mothers taking this medicine.

•    if you have any of the following medical problems: asthma, bronchitis, emphysema, or other chronic lung disease; epilepsy or history of convulsions; hyperactivity (in children); kidney or liver disease; mental depression or illness; myasthenia gravis, porphyria.

Treatment

This medication is used to relieve or prevent the symptoms of your medical problem. Take the medicine as directed. Do not take more of them and do not take them more often than recommended on the label, unless otherwise directed by your doctor.

•    Usual dosage: The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regime. The usual dosage for adults

amounts to 15-30 mg at bedtime. The dose may be individualized for maximum benefit, The starting dose for seniors is 15 mg. The medicine is not recommended for children under 15 years of age.

•    Benzodiazepine drugs can be abused if taken for long periods of time and it is possible to develop withdrawal symptoms if you discontinue the therapy abruptly. This medicine can cause drug withdrawal symptoms if suddenly discontinued. Withdrawal symptoms include:

•   Tremors

•   Muscle cramps

•   Insomnia

•   Agitation

•   Diarrhea

•   Vomiting

•   Sweating

•   Convulsions

Cautions and Warnings

•    Do not take this drug if you are allergic or sensitive to any of its ingredients.

•    The drug has been associated with memory loss, especially when higher doses are taken. This effect, known as “traveller’s amnesia,” is most common among people who take this medicine to adjust to time zone changes during travel.

•    If you abruptly stop taking this medicine, you may experience rebound sleeplessness, where sleeplessness is worse during the first 1-3 nights, after you stop the drug that it was before you started it.

•    People with reparatory disease may experience sleep apnea (intermittent cessation of breathing during sleep) while taking this medicine.

•    People with kidney or liver disease would be carefully monitored while taking this medicine. Take the lowest possible dose to help you sleep.

•    Clinical depression may be increased by this medicine, which can depress the nervous system. Intentional overdose is more common among depressed people, who take sleeping pills that among those who do not.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects.

•    Minor side effects are:

Bitter taste in the mouth

Dizziness

Drowsiness

Depression

Constipation

Dry mouth

Excessive salivation

Fatigue

Flushing

Headache

Heartburn

Loss of appetite

Nausea

Nervousness

Sweating

Vomiting.

As your body adjusts to the medicine, these side effects should  disappear.

•    Tell your doctor about any side effects that are persistent or particularly bothersome. It is especially important to tell your doctor about:

Blurred or double vision

Chest pain

Difficulty in urinating

Fainting or falling

Fever or hallucinations

Joint pain

Mouth sores

Nightmares

Palpitations

Severe depression

Shortness of breath

Slurred speech

Uncoordinated movements

Unusual tiredness

Yellowing of the skin

Interactions

This medicine may interact with several other drugs. This medicine will add to the effects of alcohol, and CNS depressants.

•    Be sure to tell your doctor about any medications you are currently taking.

Overdosage

The most common symptoms of overdose are:

•   Confusion

•   Sleepiness

•   Loss of muscle coordination

•   Slurred speech

Overdose victims must be made to vomit, with ipecac syrup, to remove any remaining drug from the stomach. Call your doctor or a poison control  center before doing this. If 30 minutes have passed since the overdose was taken or if symptoms have begun to develop, the victim must immediately be taken to a hospital emergency  room.

Storage

Store at room temperature in tightly closed, light-resistant containers. Keep out of the reach of children since overdose may be especially dangerous in children.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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