This medicine contains as active ingredient ethacrynic acid, a short-acting loop diuretic, used to treat fluid retention (edema) caused by heart failure, and certain lung, liver, and kidney disorders. De drug increases the elimination of sodium, potassium and water from the body. The decreased body fluid reduced blood pressure.
Diuretics are most commonly used in the treatment of high blood pressure. By removing a larger amount of water than usual from the bloodstream, the kidneys reduce the total volume of blood circulating. The drop in volume causes a reduction of the pressure within the blood vessels.
Diuretics are also widely used to treat heart failure in which the heart’s pumping mechanism has become weak. In the treatment of this disorder, they remove fluid that has accumulated in the tissues and lungs. The resulting drop in blood volume reduces the work of the heart.
The drug is prescribed for:
• Treatment of high blood pressure.
• Treatment of fluid retention, particularly in case of heart failure
• Treatment of certain diseases of the lung, liver, and kidney.
Cautions and Warnings
Do not take loop diuretics if you are allergic or sensitive to any of their ingredients. People allergic to sulfa drugs may also be allergic to a loop diuretic.
Excessive use of loop diuretics results in dehydration or reduction in blood volume, and may cause circulatory collapse or other related problems particularly in older adults.
Ringing or buzzing in the ears, deafness, fainting, and a sensation of fullness in the ears can occur with these drugs. Hearing usually returns within 24 hours, but some loss may be permanent.
Before using this medicine
Before you use this medicine check with your doctor:
• if you ever had any unusual or allergic reaction to this drug
• if you have liver or kidney disease
• if you have gout, diabetes or impaired hearing.
• if you have surgery within two months, including dental surgery, requiring general or spinal anaesthesia
• if you are pregnant or intend to become pregnant while using this medicine. Risk factors vary for drugs in this group
• if you are breast-feeding an infant. The drug passes into the breast milk and may harm the child
• if you have prostate trouble.
This medication is used to relieve or prevent the symptoms of your medical problem. Take them as directed. Do not take more of them and do not take them more often than recommended on the label, unless otherwise directed by your doctor.
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regime.
Adult: 50-200 mg taken every day or every other day. Child: starting dose: 25 mg; may be increased slowly. Do not change the dosage or stop taking your medication without your doctor’s approval.
Tablet or liquid: swallow with liquid. If you can not swallow whole, crumble tablet and take with liquid or food.
When to take: 1 dose a day; take after breakfast. If more than 1 dose a day: take last dose no later than 18.00 hr. unless otherwise directed.
Diet advice: eat plenty of potassium-rich fresh fruits and vegetables.
Along with the needed effects, a medicine may cause some unwanted effects. Side effects include:
• Mood changes
• Appetite loss
• Irregular heartbeat
• Muscle cramps
• Low blood pressure
• Abdominal pain
• Rash or hives
• Sore throat
Symptoms of overdose are:
• Nausea or vomiting
• Leg muscle cramps
• Weak and rapid pulse
Call a doctor or emergency room of hospital. If necessary, give first aid immediately.
This medicine may interact with several other drugs such as non-steroidal anti-inflammatory medicines, lithium, digitalis preparations, anticoagulants, oral diabetics, antihypertensives, antivirals, barbiturates.
Be sure to tell your doctor about any medications you are currently taking.
Driving or hazardous work
Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places.
Store at room temperature in tightly closed, light-resistant containers. Keep out of the reach of children. Protect from light.