Cholestyramine

Cholestyramine

Properties

This medicine contains cholestyramine as active ingredient. It is a a resin that binds bile acids in the intestine, preventing their  reabsorption.

Cholesterol in the body is normally converted to bile acids. Therefore, the use of this medicine results in a reduction of cholesterol in the blood. The medicine works entirely within the bowel and is never absorbed into the bloodstream. Though usually given 3-4 times a day, there appears to be no advantage to taking it more often than twice a  day.

Prescribed for

The medicine is prescribed for:

•   Removal of excess bile acids that occur with some liver problems

•   Lowering of cholesterol levels

•   Colitis

Cautions and Warnings

This medicine interferes with the absorption of virtually all oral drugs, including acetaminophen, amiodarone, aspirin, clindamycin, contraceptive drugs, thiazide diuretics, etc.

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

•   if you ever had any unusual or allergic reaction to this medication

•    if you are pregnant or intend to become pregnant while using this medicine

•    if you are breast-feeding an infant; no problem expected, but consult your doctor

•   if you have angina, heart or blood-vessel disease

•   if you have a liver disorder, characterized by jaundice

•   if you have stomach problems (including ulcer)

•   if you have constipation or hemorrhoids

•   if you have kidney disease.

Treatment

This medication is used for treatment of high cholesterol levels or excess bile acids. The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage   or stop taking your medication without your doctor’s  approval.

Powder, granules: sprinkle into 8 oz. liquid. Let stand for 2 minutes, then mix with liquid before swallowing. Or mix with cereal, soup or pulpy  fruit.

When to take: 3 or 4 times a day on an empty stomach, 1 hour before or 2 hours after eating.

Children: the drug is not recommended for children under 6  years.

Diet: a low-fat, low-calorie diet may be advised for patients who are overweight.

Side effects

Along with the needed effects, a medicine may cause some unwanted effects. Possible side effects include:

•   Constipation

•   Belching

•   Diarrhea

•   Bloating

•   Mild nausea

•   Vomiting

•   Stomach pain

•   Heartburn

•   Black, tarry stool

•   Rash

•   Hives

•   Sore tongue

Overdose

Increased side effects and adverse reactions are a sign of overdose. An overdose is unlikely to threaten life.

Call a doctor or hospital emergency room for  instructions.

Interactions

This medicine reduces the body’s ability to absorb other drugs. The dosage of other drugs may need to be adjusted. Possible interaction with other drugs may occur: systemic adrenocorticoids, oral anticoagulants, digitalis preparations, thiazides, vitamins.

Be sure to tell your doctor about any medications you are currently  taking.

Driving or hazardous work

No problems expected.

Storage

Powder, granules should be stored at room temperature; store away from heat and direct light. Keep out of reach of children, since overdose may be dangerous in children.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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