CHOLANGIOCARCINOMA OF THE LIVER
This liver Tumours develops from the epithelial cells of the bile duct and occurs more often in males than females; it is 15 times less common than hepatocellular carcinoma. It occurs in individuals about 10 years older than those with hepatocellular carcinoma, and chronic liver disease is not such an important etiological feature. In patients with ulcerative colitis, the risk of biliary tract Tumours is about ten times greater than in the general population and may be related to the duration and severity of the colitis. This association is particularly seen in patients of certain HLA haplotypes (HLA B8). Familial aggregation of biliary tract Tumours is rarely reported. Periampullary cancers are seen in familial adenomatous polyposis (FAP), and bile duct cancers may also occur with congenital dilatation of the bile ducts or with congenital absence of the gallbladder and cystic ducts.