Avapro

Avapro

Properties

This medicine contains irbesartan as active ingredient. It belongs to the class of medicines known as angiotensin II blockers. Angiotensin II is a hormone found in blood vessels and other tissues; it plays an important role in regulating blood pressure. This medicine works, in part, by preventing the hormone angiotensin II from constricting the blood vessels, which tends to raise blood pressure.

Angiotensin II blockers may be used alone or with a thiazide diuretic. Combining an angiotensin II blocker and a diuretic may reduce blood pressure twice as much as an angiotensin II blocker alone.

Used mainly in circulatory conditions (such as hypertension) these drugs are occasionally prescribed for other conditions. The medicine does not cure hypertension, it only controls the symptoms, so it may have to be taken continuously over a long  period.

Prescribed for

The medicine is prescribed for:

  • Treatment of high blood pressure
  • May be useful in treating heart failure
  • May be used to slow the progress of kidney disease in type 2 diabetes

Cautions and Warnings

People with heart failure given this medication generally experience a drop in blood pressure. If this happens, a temporary dosage reduction may be needed.

People treated with diuretics may also experience a sudden drop in blood pressure (symptoms include dizziness and fainting). Once your body has adjusted to this medication, the problem should subside.

People with serious liver disease or cirrhosis should receive a lower starting dosage.

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

  • if you ever had any unusual or allergic reaction to angiotensin II blockers
  • if you are pregnant or intend to become pregnant while using this medicine
  • if you have low blood pressure
  • if you have kidney or liver disease
  • if you are breast-feeding an infant.

Treatment

This medication is used for treatment of hypertension and certain heart conditions.

Usual dosage

The information below is based on the dosage guidelines your doctor uses.

Depending on your condition and medical history, your doctor may prescribe a different regime. Do not change the dosage or stop taking your medication without your doctor’s approval.

Adult: 150 mg once a day to start, increasing gradually up to 300 mg once a day if necessary. Child: not recommended.

Tablets, capsules or extended-release tablets should be taken with liquid. Take it at the same time each day.

Side effects

Along with the needed effects, a medicine may cause some unwanted effects. The medicine is generally well tolerated. Possible side effects include:

  • Respiratory infection
  • Dizziness
  • Headache
  • Fatigue
  • Diarrhea
  • Nausea and vomiting
  • Abdominal and other pain
  • Joint pain
  • Sinus problems
  • Sore throat
  • Runny nose
  • Bronchitis
  • Chest pain
  • Changes in urinary frequency
  • Swollen arms or legs

Overdose

The following symptoms may be a sign of overdose: low blood pressure and abnormally rapid or slow heartbeat.

Call a doctor or hospital emergency room for instructions. If necessary start first aid immediately.

Interactions

The effect of this medicine may cause a blood pressure drop if taken together with antihypertensives, antidiabetics, antihistamines and diuretics.

Be sure to tell your doctor about any medications you are currently  taking.

Driving and hazardous work

Do not drive a car until you learn how this medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes.

Storage

Capsules, tablets, etc. should be stored at in a tightly closed container in a cool, dry place; store away from heat and direct light. Keep out of reach of children, since this medicine may be dangerous in  children.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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