Aripripazole

Aripripazole

Properties

This medicine contains aripripazole as active ingredient. It belongs to the new class of psychoactive medicines, that has a specific effect on certain neurotransmitters, the chemical messengers in the brain. The drug works on serotonin and dopamine receptors in the brain. Unlike other newer psychoactive medicines that only decrease dopamine, it may both increase and decrease dopamine, targeting specific areas of the brain where the neurotransmitter is too plentiful or too reduced. However, the exact way it works is not known. Studies have proved its effectiveness for 6 months or beyond.

Prescribed for

The medicine is prescribed for:

  • Schizophrenia (adults and adolescents)
  • Bipolar disorder (adults, adolescents and children)
  • Major depression (adults)

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

  • if you ever had any unusual or allergic reaction to this medicine or any psychoactive drug;
  • if you are pregnant or intend to become pregnant while using this medicine;
  • if you are breast-feeding an infant;
  • if you have liver or kidney disease;
  • if you have a heart problem;
  • if you have a history of seizures (convulsions, epilepsy).

Cautions and Warnings

  • Elderly patients, diagnosed with psychosis as a result of dementia (for example, an inability to perform daily activities as a result of increased memory loss), and who are treated with antispsychotic medicines are at an increased risk of death when compared to patients who are treated with a placebo (sugar pill). This medicine is not approved for the treatment of patients with dementia-related psychosis.
  • Some medicines can increase suicidal thoughts and behaviors in children, teens, and young adults. Serious mental illness are themselves associated with an increase in the risk of suicide. When taking this medicine, call your doctor right away if you have new of worsening mood symptoms, unusual changes in behavior, or thoughts of suicide. Patients and their caregivers should be especially observant within the first few months of treatment or after a change in dose.
  • Patients and their families or caregivers should watch for new or worsening mood symptoms, unusual changes in behavior and thoughts, as well as for the following symptoms:
  • Anxiety
  • Agitation
  • Panic attacks
  • Difficulty sleeping
  • Irritability
  • Hostility
  • Aggressiveness
  • Impulsivity
  • Restlessness
  • Extreme hyperactivity
  • Report any sudden changes in temperature, heart rate (arrhythmias) or heart palpitations to your doctor as these may be symptoms of a serious side effect.
  • Because this medicine has the potential to impair judgment, thinking, or motor skills, use caution when operating machinery,  including automobiles, until you know how this medicine affects Avoid drinking alcohol. Avoid strenuous exercise, or prolonged exposure to heat,   since this could contribute to a rise in core body temperature, and dehydration.

Treatment

  • This medication is used for treatment of severe mental, nervous and emotional The drug is known to help the management of signs and symptoms of schizophrenia, bipolar disorders and major depression.
  • Usual dose: The information below is based on the dosage guidelines your doctor Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor’s approval.

This medicine is usually taken once a day, with or without food: 10-15 mg. The dose can be increased to 30 mg daily if needed. Treatment may be as long as 6 weeks. For children and adolescents the recommended dose is 10 mg; the initial dose is usually 2 mg. For patients who must limit their sugar intake, be aware that this medicine contains sugar.

If you forget to take a dose of this medicine, take it as soon you remember and continue with your regular dose on the next day. Tell your doctor or pharmacist if you forget more than one dose of this  medicine.

  • Serious side effects occur with any antipsychotic Tell your healthcare professional right away if you have any conditions, including the following:
  • Stroke or ministroke in elderly patients with dementia
  • Neuroleptic malignant syndrome
  • Tardive dyskinesia
  • High blood sugar and diabetes
  • Orthostatic hypotension
  • Suicidal thoughts
  • Dysphagia
  • Do not discontinue the use of this drug without consulting your Dosage may require a gradual reduction before stopping.
  • Tell your healthcare provider:
  • About any medical conditions you may have
  • Whether you’re taking any other prescription medicines
  • Whether you are taking any over-the-counter medicines
  • If you or anyone in your family has seizues
  • For safe and effective use of medicine: Follow your doctor’s instructions if this medicine was Follow the manufacturer’s package directions if you are treating yourself.

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects. Possible side effects include:

Drowsiness

Anxiety

Insomnia

Sleepiness

Nausea

Vomiting

Constipation

Headache

Extrapyramidal disorder

Dizziness

Uncontrolled movement disorders

Restlessness

Involuntary movements

Tremors

Muscle stiffness

Prolonged, abnormal muscle spasm

Interactions

This medicine can be taken with most drugs, however, taking this drug with some other medicines may require your healthcare professional to adjust the dosage:

  • Ketoconazole
  • Quinidine
  • Fluoxetine
  • Paroxetine
  • Carbamazepine

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.

Overdose

The following symptoms may be a sign of overdose:

Extreme drowsiness

Rapid heartbeat

Faintness

Convulsions

Difficulty in breathing

Excessive sweating

Call a doctor or hospital emergency room for instructions. If necessary start first aid immediately.

Storage

Tablets and oral solution should be stored at room temperature; store away from heat and direct light. Keep out of reach of children, since this medicine may be dangerous in  children.

KNOWLEDGE BASE
About Genomic Medicine UK

Genomic Medicine UK is the home of comprehensive genomic testing in London. Our consultant medical doctors work tirelessly to provide the highest standards of medical laboratory testing for personalised medical treatments, genomic risk assessments for common diseases and genomic risk assessment for cancers at an affordable cost for everybody. We use state-of-the-art modern technologies of next-generation sequencing and DNA chip microarray to provide all of our patients and partner doctors with a reliable, evidence-based, thorough and valuable medical service.

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