This medicine contains amoxapine as active ingredient. It belongs to the group of medicines known as tricyclic antidepressants or “mood elevators.” It is used to relieve mental depression and depression that  sometimes occurs with anxiety. The medication gradually relieves, but does not cure, symptoms of depression.

The medication Influences the passage of certain brain chemicals – serotonin and/or norepinephrine – in and out nerve endings, producing an alteration of the excitatory levels of nerve cells. They also counteract the effects of the neurohormone or neurotransmitter acetylcholine.

The medicine works by causing long-term changes in the way the neurotransmitters in the central nervous system work. The medicines  of this type can elevate mood, increase physical activity and mental alertness, and improve appetite and sleep patterns after 2-4 weeks of use.

Prescribed for

The medication is prescribed for:

  • Depression with or without symptoms of anxiety
  • Neurotic or psychotic depressive disorder
  • Narcolepsy
  • Bulimia
  • Panic attacks
  • Cocaine withdrawal syndrome
  • Attention deficit disorder

Before using this medicine

Before you use this medicine check with your doctor, or  pharmacist:

  • if you ever had any unusual or allergic reaction to any tricyclic antidepressant, maprotiline or
  • if you are on a low-salt, low-sugar, or any other special diet, or if you are allergic to any substance, such as sulfites or other preservatives or dyes.
  • if you are pregnant or intend to become pregnant while using this There have been reports of newborns suffering from heart, breathing, and urinary problems when their mothers had taken tricyclic antidepressants before delivery.
  • if you are breast-feeding an infant. Some tricyclic antidepressants pass into the breast milk.


  • Take this medicine only as directed by your doctor, to benefit your condition as much as Do not take more of it, do not take it more often, and do not take it for a longer period of time than your doctor ordered.
  • Usual dosage: The information below is based on the dosage guidelines your doctor Depending on your condition and medical history, your doctor may prescribe a different regime. Adults and children (age 18 and over): 100-400 mg a day. Hospitalized patients may take up to 600 mg a day if needed. Lower doses are recommended for seniors; generally 30-50 mg a day.
  • To lessen stomach upset, take this medicine with food, even for a daily bedtime dose, unless your doctor has told you to take it on an empty If you forget your once-a-day bedtime dose, do not take it more than 3 hours late. If more than 3 hours, wait for next scheduled dose.
  • Sometimes this medicine must be taken for several weeks before you begin to feel better.

Cautions and Warnings

  • Do not take this type of antidepressants if you are allergic or sensitive to any of their
  • Antidepressants have been associated with an increased risk of suicide, especially in teenagers tasking them. Suicide is always a risk in severely depressed people, who should only be allowed to have minimal quantities of medicines in their possession.
  • These drugs should be taken with caution if you have a history of:
  • Convulsive disorders
  • Seizures
  • Difficulty urinating
  • Glaucoma
  • Hearty disease
  • Liver disease
  • Hyperthyroidism

Side Effects

Along with the needed effects, a medicine may cause some unwanted effects. Side effects that usually do not require medical attention: difficult or frequent urination; decreased sex drive; muscle aches; abnormal dreams; nasal congestion; weakness and faintness when arising from bed or chair; back pain.

  • Other side effects that should be reported to your doctor immediately are:
    • Hallucinations
    • Shakiness
    • Confusion
    • Disorientation
    • Muscle spasms
    • Tremors
    • Worsening glaucoma
    • Sensitivity to bright light
    • Seizures
    • Constipation
    • Difficulty urinating
    • Convulsions
    • Dizziness
    • Fainting
    • Blurred vision
    • Eye pain
    • Irregular heartbeat or slow pulse
    • Inflamed tongue
    • Abdominal pain
    • Jaundice
    • Hair loss
    • Rash
    • Fever
    • Chills
    • Joint pain
    • Palpitations

Driving or Hazardous Work

Do not drive until you learn how the medicine affects you. Do not work around dangerous machinery. Do not climb ladders or work in high places. Danger increases if you drink alcohol or take medicines affecting alertness and reflexes.


This medicine may interact with several other drugs such as:

  • Anticoagulants
  • Anticholinergics
  • Cold remedies
  • Oral contraceptives
  • Estrogens
  • Seizure medicines
  • Sleeping medicines
  • Thyroid medicines
  • Other antidepressants
  • Be sure to tell your doctor about any medications you are currently taking.


Tablets, capsules, etc. should be stored at room temperature in tightly closed, light-resistant containers as directed by your pharmacist. Keep  out of reach of children since overdose is especially dangerous in young children. Do not store in the bathroom medicine cabinet because the heart or moisture may cause the medicine to break down. Keep the liquid form of the medicine from freezing.

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